Mitochondrial Health: The Key to Your Health and Energy

Tired of feeling tired?
Feeling like your energy levels are never as high as they used to be?
Fixing the problem might not be as simple as getting more sleep (thought that does play a part); rather, it could be that your mitochondrial health is to blame. Mitochondria are tiny, energy-producing organelles that play a vital role in the production of ATP (the primary energy currency of cells). When they are functioning optimally, they support overall health and well-being.(1)
So, how can you support your mitochondria and make sure that they are performing as they should? Let’s explore two approaches: biohacks and supplements. Both have significant benefits to consider.
Biohacks for Mitochondrial Health
Biohacks, or lifestyle and behavior changes, that are thought to support mitochondrial health include:(2)
Exercise: Regular physical activity has been shown to improve mitochondrial function and increase the number of mitochondria in cells. This is likely due to the fact that exercise stimulates the production of reactive oxygen species (ROS), which can trigger the production of new mitochondria through a process known as mitophagy where the old, dysfunctional mitochondria are “cleaned out”.
Diet: A healthy, balanced diet that is rich in fruits and vegetables with high antioxidant and anti-inflammatory compounds supports mitochondrial health by reducing oxidative stress.(3) The best place to start is by focusing on a whole food diet.
- The Keto Diet is a great way to optimize mitochondria, because if you are metabolically dysfunctional and insulin resistant, this a good way to provide fat as an alternative fuel source rather than glucose. For those who are overweight and insulin resistant, keto can be like turning the lights on for them.
- Intermittent Fasting is another way to help raise ketones and promote mitochondrial biogenesis. It also stimulates autophagy, which is a form of cellular detox, cleaning up those cells, and mitophagy.
Sleep: Adequate sleep is important for maintaining overall health and well-being, and it may also support healthy mitochondria. During sleep, the body is able to repair and regenerate cells, including mitochondria. As mentioned previously, sleep won’t fix the entire issue of feeling sluggish and run down but if you’re struggling with low energy levels, make sure to prioritize getting enough sleep each night so your body can recover.(4)
Stress management: Chronic stress can have negative effects on mitochondria, so it is important to find ways to manage stress effectively. This may include practices such as meditation, yoga, or other stress-reducing techniques. So, if you’re looking to support the health of your mitochondria, make sure to incorporate stress-management techniques into your routine.(5)
Supplements for Mitochondrial Health
There are a number of supplements that have been studied for their potential benefits for mitochondrial health, including:
Coenzyme Q10 (CoQ10) is an antioxidant found naturally in the body that helps produce energy. Supplementation with CoQ10 has been shown to improve mitochondrial function.(6)
Creatine is a compound found naturally in the body that helps muscle function. Additionally, it supports mitochondrial function and may have protective effects on mitochondria. Creatine is definitely worth considering.(7)
Alpha-lipoic acid is an antioxidant that has been shown to improve mitochondrial function and may have protective effects on mitochondria.(8)
Acetyl-L-carnitine is a highly bioavailable form of carnitine that can cross the blood-brain barrier, where it helps to manage typical oxidative stress, supports mitochondrial function and helps maintain neurotransmitter activity.(9)
Polyphenols enhance the mitochondrial efficiency and stimulate mitochondrial biogenesis (increasing size and number of mitochondria). They stimulate autophagy (cellular detoxification) and promote mitophagy. Lastly, “studies have shown that dietary polyphenols can regulate mitochondrial redox status, and in some cases, prevent or delay disease progression.”
What’s The Best Approach?
The truth is that both biohacks and supplements can be effective. A balanced diet, regular physical activity and stress management are all important for maintaining overall health and well-being. Additionally, it is always a good idea to consult with a healthcare professional before starting any new supplement regimen, as certain supplements may interact with medications or have other potential risks or side effects. So, if you’re looking to support and improve the health of your mitochondria, consider incorporating both biohacks and supplements into your routine. Your energy levels (and overall health) will thank you!
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Sources:
- Javadov, Sabzali, et al. “Mitochondria in Health and Diseases.” Cells, U.S. National Library of Medicine, 9 May 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290976.
- Huertas, Jesus R, et al. “Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm.” Oxidative Medicine and Cellular Longevity, U.S. National Library of Medicine, 19 June 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607712/.
- Author links open overlay panelE.WesselinkaEnvelopeW.A.C.KoekkoekbEnvelopeS.GreftecEnvelopeR.F.WitkampaEnvelopeA.R.H.van ZantenbPersonEnvelope, et al. “Feeding Mitochondria: Potential Role of Nutritional Components to Improve Critical Illness Convalescence.” Clinical Nutrition, Churchill Livingstone, 31 Aug. 2018, https://www.sciencedirect.com/science/article/pii/S0261561418324269.
- Melhuish Beaupre LM;Brown GM;Braganza NA;Kennedy JL;Gonçalves VF; “Mitochondria’s Role in Sleep: Novel Insights from Sleep Deprivation and Restriction Studies.” The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/33821750/.
- Picard, Martin, and Bruce S McEwen. “Psychological Stress and Mitochondria: A Systematic Review.” Psychosomatic Medicine, U.S. National Library of Medicine, 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901654.
- Quinzii, Catarina M, and Michio Hirano. “Coenzyme Q and Mitochondrial Disease.” Developmental Disabilities Research Reviews, U.S. National Library of Medicine, 2010, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097389/.
- Barbieri, Elena, et al. “Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity.” Oxidative Medicine and Cellular Longevity, U.S. National Library of Medicine, 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005540.
- Dos Santos SM;Romeiro CFR;Rodrigues CA;Cerqueira ARL;Monteiro MC; “Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer’s Disease?” Oxidative Medicine and Cellular Longevity, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/31885820/.
- Virmani, Mohamed Ashraf, and Maria Cirulli. “The Role of L-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation.” International Journal of Molecular Sciences, U.S. National Library of Medicine, 28 Feb. 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910660.
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Who is Shawn Wells?
Although I’ve suffered from countless issues, including chronic pain, auto-immunity, and depression, those are the very struggles that have led me to becoming a biochemist, formulation scientist, dietitian, and sports nutritionist who is now thriving. My personal experiences, experiments, and trials also have a much deeper purpose: To serve you, educate you, and ultimately help you optimize your health and longevity, reduce pain, and live your best life.
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