Hormones That May Be Disrupting Your Brain’s Performance

If you’ve been feeling foggy, forgetful, or just not quite like yourself mentally, your hormones could be playing a bigger role than you realize. These symptoms aren’t just random—they may be signs of brain hormone imbalance symptoms that are often overlooked, especially in women between 30 and 55.

Hormones act as chemical messengers, influencing everything from mood to memory. When even one of them falls out of balance, it can disrupt how your brain functions—slowing your thinking, muddling your memory, and affecting your emotional resilience.

And here’s the tricky part: these shifts are common in midlife. Between perimenopause, changing sleep patterns, stress, and metabolic shifts, hormone imbalances can quietly sabotage your brain health over time.

Let’s walk through four key hormones that are critical to your cognitive function—and how imbalances in each one might be showing up in your day-to-day life.

1. Estrogen: More Than Just a Reproductive Hormone

Estrogen is often associated with menstrual cycles and menopause, but it’s also a brain-protective powerhouse.

This hormone helps regulate neurogenesis (the growth of new brain cells), reduces oxidative stress, supports synaptic plasticity (a fancy term for how well your brain can adapt and learn), and boosts levels of brain-derived neurotrophic factor (BDNF)—a protein critical for memory and learning.

What happens when estrogen dips?

Low estrogen—particularly during menopause—has been linked to:

• Memory issues and brain fog
• Slower processing speeds
• Increased risk of Alzheimer’s disease
• Mood swings and depression

These are all classic brain hormone imbalance symptoms, and they’re often brushed off as “just part of aging.” But the truth is, declining estrogen can change how your brain operates. This is why it’s so important to support hormonal health—especially during midlife.

2. Insulin: Fuel for Your Brain Cells

When people think of insulin, they usually think of blood sugar. But insulin is also essential for brain energy metabolism—in other words, giving your brain cells the fuel they need to function.

It also plays a key role in neurotransmitter activity, helping with the release of acetylcholine and dopamine—two chemicals that affect memory, mood, and cognitive sharpness.

What happens when insulin is out of balance?

Too much insulin, often due to excess sugar intake or poor metabolic health, can lead to insulin resistance—a condition where your brain stops responding properly to insulin’s signals. This can lead to:

• Brain fog
• Sluggish thinking
• Memory lapses
• Increased risk of Alzheimer’s (sometimes called “Type 3 Diabetes”)

On the flip side, if insulin is too low, your brain cells don’t get the energy they need—making it harder to stay focused or alert.

Imbalances here are surprisingly common and are a huge driver of the brain hormone imbalance symptoms many women experience in midlife.

3. Melatonin: The Brain’s Night Shift Manager

Melatonin isn’t just your “sleep hormone.” It plays a much bigger role in long-term brain health than most people realize.

Produced in the brain’s pineal gland, melatonin helps regulate your circadian rhythm, ensuring you get deep, restorative sleep. This is when your brain performs critical maintenance—like consolidating memories, detoxifying waste, and recalibrating neurotransmitters.

What happens when melatonin is low?

Low melatonin levels can throw off your body’s internal clock and impact how effectively your brain resets at night. Over time, this can lead to:

• Trouble concentrating
• Irritability or mood swings
• Memory problems
• Increased brain inflammation
• Greater buildup of beta-amyloid plaques—one of the hallmarks of Alzheimer’s disease

This is one of the sneakier brain hormone imbalance symptoms because it often hides behind poor sleep quality. But addressing melatonin imbalances can be a game changer for both brain performance and emotional well-being.

4. Cortisol: Your Stress Regulator (and Sometimes Brain Saboteur)

Cortisol is the hormone your body releases in response to stress—whether it’s a work deadline, blood sugar crash, or emotional overwhelm. It’s essential for short-term survival… but chronic stress can push cortisol into overdrive, with major consequences for the brain.

What happens when cortisol is chronically high?

When cortisol levels stay elevated for too long, your brain literally starts to change—especially in areas like the hippocampus, which handles memory and learning. This can lead to:

• Memory loss and confusion
• Difficulty making decisions
• Emotional dysregulation
• Shrinkage of brain volume over time
• Reduced growth of new brain cells (neurogenesis)

These are all serious brain hormone imbalance symptoms that are becoming more and more common in high-stress lifestyles. Even when we think we’re “managing,” the body keeps the score.

Supporting Hormonal Balance Through the Mediterranean-Style Eating Pattern

Here’s some good news: one of the most powerful tools to rebalance your hormones and support cognitive health is right on your plate.

Adopting a Mediterranean-style eating pattern—rich in healthy fats, colorful veggies, lean proteins, and antioxidant-packed foods—has been shown to regulate hormone levels and protect the brain from long-term damage.

What makes the Mediterranean diet so effective?

• Healthy fats (like those from olive oil and fatty fish) support estrogen and melatonin production and help fight oxidative stress
• Polyphenols from berries, greens, and herbs reduce brain inflammation and insulin resistance
• Fiber-rich foods like legumes and whole grains help regulate cortisol and stabilize blood sugar
• Nutrients like magnesium, omega-3s, and B vitamins promote neurotransmitter balance and protect against cognitive decline

This way of eating isn’t just good for your hormones—it’s a proven strategy for long-term brain health, making it especially helpful for women navigating midlife hormonal shifts.

If you’ve been wondering “What is a typical day on a Mediterranean diet?” or looking for a Mediterranean-style eating pattern meal plan, start by adding just one or two brain-friendly meals a day. Think salmon with roasted veggies and quinoa, or a Greek salad with olive oil and walnuts. Small changes add up fast.

A Science-Backed Brain Supplement to Fill the Gaps

As someone who’s spent decades researching supplements and formulating them myself, I’m pretty picky about what I put into my body. When it comes to supporting my own brain health—especially through those hormonal ebbs and flows—I lean on strategies grounded in science.

That’s why I personally use and trust RELEVATE.

It’s formulated with 17 nutrients inspired by the Mediterranean and MIND diets, and it supports key brain functions like memory, mental clarity, and neuroprotection. What I love most is how thoughtfully it’s designed—backed by clinical research and aligned with how we should be nourishing the brain daily, especially when we’re facing brain hormone imbalance symptoms tied to aging, stress, or hormonal shifts.

If you’re already making changes to eat more Mediterranean-style or are curious about what that looks like in daily life, RELEVATE can be a solid complement to help fill in those nutritional gaps.

Use my code SHAWNW at checkout for $20 off your order.

References

Carruba, G., D’Alessandro, N., Amodio, V., Lo Casto, M., Traina, A., Cocciadiferro, L., & Di Carlo, A. (2006). A traditional Mediterranean diet decreases endogenous estrogens in healthy postmenopausal women. Nutrition and Cancer, 56(2), 253–259.

Carvalho, K. M. B., Costa, P. R. F., Silva, R. D. S., Dos Santos, L. C., & de Moraes, A. C. (2018). Does the Mediterranean diet protect against stress-induced inflammatory activation in European adolescents? Nutrients, 10(2), 1–14.

Grao-Cruces, E., Calvo, J. R., Maldonado-Aibar, M. D., Millán-Linares, M. C., & Montserrat-de la Paz, S. (2023). Mediterranean diet and melatonin: A systematic review. Antioxidants, 12(3), 556.

Janicki, S. C., Sergievsky, G. H., & Schupf, N. (2010). Hormonal influences on cognition and risk for Alzheimer disease. Current Neurology and Neuroscience Reports, 10(5), 359–366.

Lee, J. G., Lee, S., Kim, Y. H., Kim, N., Kim, J. H., & Kim, D. J. (2019). The neuroprotective effects of melatonin. Brain Sciences, 9(10), 285.

Li, R., Cui, J., & Shen, Y. (2014). Brain sex matters: Estrogen in cognition and Alzheimer’s disease. Molecular and Cellular Endocrinology, 389(1–2), 13–21.

Lin, L., Huang, Q. X., Yang, S. S., Chu, J., Wang, J. Z., & Tian, Q. (2013). Melatonin in Alzheimer’s disease. International Journal of Molecular Sciences, 14(7), 14575–14593.

Mirabelli, M., Chiefari, E., Caroleo, P., Puccio, L., Vero, R., & Brunetti, A. (2020). Mediterranean diet nutrients against insulin resistance. Nutrients, 12(4), 1066.

Nguyen, T. T., Ta, Q. T. H., Nguyen, T. K. O., Nguyen, T. T. D., & Giau, V. V. (2020). Type 3 diabetes and Alzheimer’s disease. International Journal of Molecular Sciences, 21(9), 3165.

Ouanes, S., & Popp, J. (2019). High cortisol and the risk of dementia. Frontiers in Aging Neuroscience, 11, 43.

Sȩdzikowska, A., & Szablewski, L. (2021). Insulin and insulin resistance in Alzheimer’s disease. International Journal of Molecular Sciences, 22(18), 9987.

Sohrabji, F., & Lewis, D. K. (2006). Estrogen-BDNF interactions in neurodegeneration. Frontiers in Neuroendocrinology, 27(4), 404–414.